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Altering the Double-Stranded DNA Specificity of the bZIP Domain of Zta with Site-Directed Mutagenesis at N182

[Image: see text] Zta, the Epstein–Barr virus bZIP transcription factor (TF), binds both unmethylated and methylated double-stranded DNA (dsDNA) in a sequence-specific manner. We studied the contribution of a conserved asparagine (N182) to sequence-specific dsDNA binding to four types of dsDNA: (i)...

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Detalles Bibliográficos
Autores principales: Ray, Sreejana, Tillo, Desiree, Assad, Nima, Ufot, Aniekanabasi, Porollo, Aleksey, Durell, Stewart R., Vinson, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8756438/
https://www.ncbi.nlm.nih.gov/pubmed/35036684
http://dx.doi.org/10.1021/acsomega.1c04148