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Altering the Double-Stranded DNA Specificity of the bZIP Domain of Zta with Site-Directed Mutagenesis at N182
[Image: see text] Zta, the Epstein–Barr virus bZIP transcription factor (TF), binds both unmethylated and methylated double-stranded DNA (dsDNA) in a sequence-specific manner. We studied the contribution of a conserved asparagine (N182) to sequence-specific dsDNA binding to four types of dsDNA: (i)...
Autores principales: | Ray, Sreejana, Tillo, Desiree, Assad, Nima, Ufot, Aniekanabasi, Porollo, Aleksey, Durell, Stewart R., Vinson, Charles |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8756438/ https://www.ncbi.nlm.nih.gov/pubmed/35036684 http://dx.doi.org/10.1021/acsomega.1c04148 |
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