Cargando…

Synthesis, Bioactivity Assessment, and Molecular Docking of Non-sulfonamide Benzimidazole-Derived N-Acylhydrazone Scaffolds as Carbonic Anhydrase-II Inhibitors

[Image: see text] This research reports the synthesis of new benzimidazole-derived N-acylhydrazones (NAH), their characterization using various spectroscopic methods, and in vitro evaluation as potent carbonic anhydrase-II inhibitors. Among the target compounds (9–29), few showed higher inhibition t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Saadiq, Muhammad, Uddin, Ghias, Latif, Abdul, Ali, Mumtaz, Akbar, Nazia, Ammara, Ali, Sardar, Ahmad, Manzoor, Zahoor, Mohammad, Khan, Ajmal, Al-Harrasi, Ahmed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8756595/ https://www.ncbi.nlm.nih.gov/pubmed/35036737 http://dx.doi.org/10.1021/acsomega.1c05362

Ejemplares similares

Novel 5-(Arylideneamino)-1H-Benzo[d]imidazole-2-thiols as Potent Anti-Diabetic Agents: Synthesis, In Vitro α-Glucosidase Inhibition, and Molecular Docking Studies
por: Ali, Sardar, et al.
Publicado: (2022)

New supramolecules of bis(acylhydrazones)-linked bisphenol sulfide for Alzheimer's: targeting cholinesterases by in vitro and in silico approaches
por: Ibrahim, Muhammad, et al.
Publicado: (2023)

New sulfonamides containing organometallic-acylhydrazones: synthesis, characterisation and biological evaluation as inhibitors of human carbonic anhydrases
por: Huentupil, Yosselin, et al.
Publicado: (2019)

Mercaptobenzimidazole-Based 1,3-Thaizolidin-4-ones as Antidiabetic Agents: Synthesis, In Vitro α-Glucosidase Inhibition Activity, and Molecular Docking Studies
por: Khan, Sher Ali, et al.
Publicado: (2022)

Novel 2-substituted-benzimidazole-6-sulfonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IX and XII and molecular docking studies
por: Milite, Ciro, et al.
Publicado: (2019)

Synthesis, Carbonic Anhydrase II/IX/XII Inhibition, DFT, and Molecular Docking Studies of Hydrazide-Sulfonamide Hybrids of 4-Methylsalicyl- and Acyl-Substituted Hydrazide
por: Khushal, Adil, et al.
Publicado: (2022)

Synthesis, Molecular Docking Analysis, and Biological Evaluations of Saccharide-Modified Sulfonamides as Carbonic Anhydrase IX Inhibitors
por: Zhang, Zuopeng, et al.
Publicado: (2021)

Design, Synthesis and Molecular Docking Study of Novel 3-Phenyl-β-Alanine-Based Oxadiazole Analogues as Potent Carbonic Anhydrase II Inhibitors
por: Rafiq, Kashif, et al.
Publicado: (2022)

Neurologically Potent Molecules from Crataegus oxyacantha; Isolation, Anticholinesterase Inhibition, and Molecular Docking
por: Ali, Mumtaz, et al.
Publicado: (2017)

Five-Membered Heterocyclic Sulfonamides as Carbonic Anhydrase Inhibitors
por: Angeli, Andrea, et al.
Publicado: (2023)

Synthesis, Antimicrobial Activity, and Molecular Docking Studies of Aminoguanidine Derivatives Containing an Acylhydrazone Moiety
por: Yao, Xiaodong, et al.
Publicado: (2021)

Docking studies and molecular dynamics simulation of triazole benzene sulfonamide derivatives with human carbonic anhydrase IX inhibition activity
por: P., Gopinath, et al.
Publicado: (2021)

Synthesis and Antibacterial Evaluation of Some Novel Imidazole and Benzimidazole Sulfonamides
por: Al-Mohammed, Nassir N., et al.
Publicado: (2013)

Chromene-Containing Aromatic Sulfonamides with Carbonic Anhydrase Inhibitory Properties
por: Angeli, Andrea, et al.
Publicado: (2021)

Docking, Synthesis and Antiproliferative Activity of N-Acylhydrazone Derivatives Designed as Combretastatin A4 Analogues
por: do Amaral, Daniel Nascimento, et al.
Publicado: (2014)

Synthesis of Benzimidazole–Based Analogs as Anti Alzheimer’s Disease Compounds and Their Molecular Docking Studies
por: Adalat, Bushra, et al.
Publicado: (2020)

Quinazolinones as Competitive Inhibitors of Carbonic Anhydrase-II (Human and Bovine): Synthesis, in-vitro, in-silico, Selectivity, and Kinetics Studies
por: Khan, Ajmal, et al.
Publicado: (2020)

From Sensors to Silencers: Quinoline- and Benzimidazole-Sulfonamides as Inhibitors for Zinc Proteases
por: Rouffet, Matthieu, et al.
Publicado: (2010)

Structural Basis for the Inhibition of Helicobacter pylori α-Carbonic Anhydrase by Sulfonamides
por: Modakh, Joyanta K., et al.
Publicado: (2015)

Acylhydrazones and Their Biological Activity: A Review
por: Socea, Laura-Ileana, et al.
Publicado: (2022)

Bio-Oriented Synthesis of Novel Polyhydroquinoline Derivatives as α-Glucosidase Inhibitor for Management of Diabetes
por: Talab, Faiz, et al.
Publicado: (2023)

Bis-pharmacophore of cinnamaldehyde-clubbed thiosemicarbazones as potent carbonic anhydrase-II inhibitors
por: Rasool, Asif, et al.
Publicado: (2022)

Saccharin Sulfonamides as Inhibitors of Carbonic Anhydrases I, II, VII, XII, and XIII
por: Morkūnaitė, Vaida, et al.
Publicado: (2014)

Correction: Structural Basis for the Inhibition of Helicobacter pylori α-Carbonic Anhydrase by Sulfonamides
Publicado: (2015)

Nanoemulsions of sulfonamide carbonic anhydrase inhibitors strongly inhibit the growth of Trypanosoma cruzi
por: Vermelho, Alane Beatriz, et al.
Publicado: (2017)

Betulin Sulfonamides as Carbonic Anhydrase Inhibitors and Anticancer Agents in Breast Cancer Cells
por: Güttler, Antje, et al.
Publicado: (2021)

Synthesis of New Benzothiazole Acylhydrazones as Anticancer Agents
por: Osmaniye, Derya, et al.
Publicado: (2018)

Bio-Oriented Synthesis of Novel (S)-Flurbiprofen Clubbed Hydrazone Schiff’s Bases for Diabetic Management: In Vitro and In Silico Studies
por: Alam, Aftab, et al.
Publicado: (2022)

Synthesis of an acridine orange sulfonamide derivative with potent carbonic anhydrase IX inhibitory action
por: Bragagni, Marco, et al.
Publicado: (2017)

2-Methyl-6-(4,4,10,13,14-pentamethyl-3-oxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)hept-2-enoic acid
por: Arfan, Mohammad, et al.
Publicado: (2011)

Molecular docking and dynamic simulations of benzimidazoles with beta-tubulins
por: Rao, Chennu Maruthi Malya Prasada, et al.
Publicado: (2021)

Acylhydrazones as Antifungal Agents Targeting the Synthesis of Fungal Sphingolipids
por: Lazzarini, Cristina, et al.
Publicado: (2018)

Identification of a strong and specific antichlamydial N-acylhydrazone
por: Zhang, Huirong, et al.
Publicado: (2017)

Antiprotozoal Activity of (E)-Cinnamic N-Acylhydrazone Derivatives
por: Carvalho, Samir Aquino, et al.
Publicado: (2014)

Crystal structures of three N-acylhydrazone isomers
por: Purandara, H., et al.
Publicado: (2021)

Benzamide-4-Sulfonamides Are Effective Human Carbonic Anhydrase I, II, VII, and IX Inhibitors
por: Abdoli, Morteza, et al.
Publicado: (2018)

Inhibition of the α-carbonic anhydrase from Vibrio cholerae with amides and sulfonamides incorporating imidazole moieties
por: De Vita, Daniela, et al.
Publicado: (2017)

Effect of Sulfonamides and Their Structurally Related Derivatives on the Activity of ι-Carbonic Anhydrase from Burkholderia territorii
por: De Luca, Viviana, et al.
Publicado: (2021)

New Carbonic Anhydrase-II Inhibitors from Marine Macro Brown Alga Dictyopteris hoytii Supported by In Silico Studies
por: Rafiq, Kashif, et al.
Publicado: (2021)

Synthesis and carbonic anhydrase I, II, VII, and IX inhibition studies with a series of benzo[d]thiazole-5- and 6-sulfonamides
por: Abdoli, Morteza, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_sqv2dbcv9d3q8ehccbo43dt0c7