Free-Energy Simulations Support a Lipophilic Binding Route for Melatonin Receptors

[Image: see text] The effects of the neurohormone melatonin are mediated by the activation of the GPCRs MT(1) and MT(2) in a variety of tissues. Crystal structures suggest ligand access to the orthosteric binding site of MT(1) and MT(2) receptors through a lateral channel between transmembrane (TM)...

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Detalles Bibliográficos
Autores principales: Elisi, Gian Marco, Scalvini, Laura, Lodola, Alessio, Mor, Marco, Rivara, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757440/
https://www.ncbi.nlm.nih.gov/pubmed/34932329
http://dx.doi.org/10.1021/acs.jcim.1c01183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757440/
https://www.ncbi.nlm.nih.gov/pubmed/34932329
http://dx.doi.org/10.1021/acs.jcim.1c01183

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