Preferential Solvation Study of the Synthesized Aldose Reductase Inhibitor (SE415) in the {PEG 400 (1) + Water (2)} Cosolvent Mixture and GastroPlus-Based Prediction

[Image: see text] (Z)-N-Benzyl-2-{2,4-dioxo-5-(4-prop-2-yl-1-yloxyl)benzylidene)thiazolin-3-yl)}acetamide (SE415) is a novel aldose reductase inhibitor used in the management of diabetes mellitus (DM) and associated complications. Herein, the drug was solubilized (mole fraction solubility) in a “PEG...

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Detalles Bibliográficos
Autores principales: Hussain, Afzal, Altamimi, Mohammad A., Afzal, Obaid, Altamimi, Abdulmalik S. A., Ali, Abuzer, Ali, Amena, Martinez, Fleming, Mohd Siddique, Mohd Usman, Acree, William E., Jouyban, Abolghasem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757459/
https://www.ncbi.nlm.nih.gov/pubmed/35036782
http://dx.doi.org/10.1021/acsomega.1c05788

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757459/
https://www.ncbi.nlm.nih.gov/pubmed/35036782
http://dx.doi.org/10.1021/acsomega.1c05788

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