Beyond bispecificity: Controlled Fab arm exchange for the generation of antibodies with multiple specificities

Controlled Fab arm exchange (cFAE) has proven to be a generic and versatile technology for the efficient generation of IgG-like bispecific antibodies (DuoBodies or DBs), with several in clinical development and one product, amivantamab, approved by the Food and Drug Administration. In this study, we...

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Detalles Bibliográficos
Autores principales: Yanakieva, Desislava, Pekar, Lukas, Evers, Andreas, Fleischer, Markus, Keller, Stephan, Mueller-Pompalla, Dirk, Toleikis, Lars, Kolmar, Harald, Zielonka, Stefan, Krah, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757479/
https://www.ncbi.nlm.nih.gov/pubmed/35014603
http://dx.doi.org/10.1080/19420862.2021.2018960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757479/
https://www.ncbi.nlm.nih.gov/pubmed/35014603
http://dx.doi.org/10.1080/19420862.2021.2018960

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