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Beyond bispecificity: Controlled Fab arm exchange for the generation of antibodies with multiple specificities

Controlled Fab arm exchange (cFAE) has proven to be a generic and versatile technology for the efficient generation of IgG-like bispecific antibodies (DuoBodies or DBs), with several in clinical development and one product, amivantamab, approved by the Food and Drug Administration. In this study, we...

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Detalles Bibliográficos
Autores principales:	Yanakieva, Desislava, Pekar, Lukas, Evers, Andreas, Fleischer, Markus, Keller, Stephan, Mueller-Pompalla, Dirk, Toleikis, Lars, Kolmar, Harald, Zielonka, Stefan, Krah, Simon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757479/ https://www.ncbi.nlm.nih.gov/pubmed/35014603 http://dx.doi.org/10.1080/19420862.2021.2018960

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