Cargando…

Personalized therapy with peptide-based neoantigen vaccine (EVX-01) including a novel adjuvant, CAF®09b, in patients with metastatic melanoma

The majority of neoantigens arise from unique mutations that are not shared between individual patients, making neoantigen-directed immunotherapy a fully personalized treatment approach. Novel technical advances in next-generation sequencing of tumor samples and artificial intelligence (AI) allow fa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mørk, Sofie Kirial, Kadivar, Mohammad, Bol, Kalijn Fredrike, Draghi, Arianna, Westergaard, Marie Christine Wulff, Skadborg, Signe Koggersbøl, Overgaard, Nana, Sørensen, Anders Bundgård, Rasmussen, Ida Svahn, Andreasen, Lars Vibe, Yde, Christina Westmose, Trolle, Thomas, Garde, Christian, Friis-Nielsen, Jens, Nørgaard, Nis, Christensen, Dennis, Kringelum, Jens Vindahl, Donia, Marco, Hadrup, Sine Reker, Svane, Inge Marie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757480/ https://www.ncbi.nlm.nih.gov/pubmed/35036074 http://dx.doi.org/10.1080/2162402X.2021.2023255

Ejemplares similares

Genetic Biomarkers in Melanoma of the Ocular Region: What the Medical Oncologist Should Know
por: Bol, Kalijn Fredrike, et al.
Publicado: (2020)

The Evx1/Evx1as gene locus regulates anterior-posterior patterning during gastrulation
por: Bell, Charles C., et al.
Publicado: (2016)

Reliable B Cell Epitope Predictions: Impacts of Method Development and Improved Benchmarking
por: Kringelum, Jens Vindahl, et al.
Publicado: (2012)

The antigen specific composition of melanoma tumor infiltrating lymphocytes?
por: Hadrup, Sine Reker
Publicado: (2012)

Molecular Analyses of V0v Spinal Interneurons and Identification of Transcriptional Regulators Downstream of Evx1 and Evx2 in these Cells
por: England, Samantha J., et al.
Publicado: (2023)

Improved T cell receptor antigen pairing through data-driven filtering of sequencing information from single cells
por: Povlsen, Helle Rus, et al.
Publicado: (2023)

Evx1 and Evx2 specify excitatory neurotransmitter fates and suppress inhibitory fates through a Pax2-independent mechanism
por: Juárez-Morales, José L., et al.
Publicado: (2016)

Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells
por: England, Samantha J., et al.
Publicado: (2023)

MHC-based detection of antigen-specific CD8(+) T cell responses
por: Hadrup, Sine Reker, et al.
Publicado: (2010)

Comment on “5-Azacytidine Promotes an Inhibitory T-Cell Phenotype and Impairs Immune Mediated Antileukemic Activity”
por: Frøsig, Thomas Mørch, et al.
Publicado: (2015)

Evolution of MHC-based technologies used for detection of antigen-responsive T cells
por: Bentzen, Amalie Kai, et al.
Publicado: (2017)

T-cell-receptor cross-recognition and strategies to select safe T-cell receptors for clinical translation
por: Bentzen, Amalie Kai, et al.
Publicado: (2019)

Corrigendum: Targeting neoantigens to APC-surface molecules improves the immunogenicity and anti-tumor efficacy of a DNA cancer vaccine
por: Barrio-Calvo, Marina, et al.
Publicado: (2023)

Targeting neoantigens to APC-surface molecules improves the immunogenicity and anti-tumor efficacy of a DNA cancer vaccine
por: Barrio-Calvo, Marina, et al.
Publicado: (2023)

“Immunotherapy of cancer: present status and future promise”: Danish Cancer Society Symposium, Copenhagen, Denmark, 23rd–25th September 2013
por: Donia, Marco, et al.
Publicado: (2014)

First in man study: Bcl-Xl_42-CAF(®)09b vaccines in patients with locally advanced prostate cancer
por: Mørk, Sofie Kirial, et al.
Publicado: (2023)

Neoepitope load, T cell signatures and PD-L2 as combined biomarker strategy for response to checkpoint inhibition immunotherapy
por: Borch, Annie, et al.
Publicado: (2023)

A novel approach for characterisation of conformational allergen epitopes combining phage display and high-throughput sequencing
por: Christiansen, Anders, et al.
Publicado: (2014)

Qualitative Analysis of Tumor-Infiltrating Lymphocytes across Human Tumor Types Reveals a Higher Proportion of Bystander CD8(+) T Cells in Non-Melanoma Cancers Compared to Melanoma
por: Gokuldass, Aishwarya, et al.
Publicado: (2020)

Real-World Impact of Immune Checkpoint Inhibitors in Metastatic Uveal Melanoma
por: Bol, Kalijn Fredrike, et al.
Publicado: (2019)

Adoptive cell therapy with tumor-infiltrating lymphocytes supported by checkpoint inhibition across multiple solid cancer types
por: Kverneland, Anders Handrup, et al.
Publicado: (2021)

Identification of an evx1-Dependent Joint-Formation Pathway during FIN Regeneration
por: Ton, Quynh V., et al.
Publicado: (2013)

Genesis and evolution of the Evx and Mox genes and the extended Hox and ParaHox gene clusters
por: Minguillón, Carolina, et al.
Publicado: (2003)

Correction: Influence of ipilimumab on expanded tumour derived T cells from patients with metastatic melanoma
por: Bjoern, Jon, et al.
Publicado: (2018)

Influence of ipilimumab on expanded tumour derived T cells from patients with metastatic melanoma
por: Bjoern, Jon, et al.
Publicado: (2017)

T Cell Epitope Prediction and Its Application to Immunotherapy
por: Schaap-Johansen, Anna-Lisa, et al.
Publicado: (2021)

Expansion With IL-15 Increases Cytotoxicity of Vγ9Vδ2 T Cells and Is Associated With Higher Levels of Cytotoxic Molecules and T-bet
por: Aehnlich, Pia, et al.
Publicado: (2020)

Evx2-Hoxd13 Intergenic Region Restricts Enhancer Association to Hoxd13 Promoter
por: Yamagishi, Takumi, et al.
Publicado: (2007)

Immune Cell Profiling of Peripheral Blood as Signature for Response During Checkpoint Inhibition Across Cancer Types
por: Araujo B. de Lima, Vinicius, et al.
Publicado: (2021)

Tumor-Infiltrating T Cells From Clear Cell Renal Cell Carcinoma Patients Recognize Neoepitopes Derived From Point and Frameshift Mutations
por: Hansen, Ulla Kring, et al.
Publicado: (2020)

Depletion of T lymphocytes is correlated with response to temozolomide in melanoma patients
por: Iversen, Trine Zeeberg, et al.
Publicado: (2013)

Broadening the repertoire of melanoma-associated T-cell epitopes
por: Frøsig, Thomas Mørch, et al.
Publicado: (2015)

Chemokine receptor engineering of T cells with CXCR2 improves homing towards subcutaneous human melanomas in xenograft mouse model
por: Idorn, Manja, et al.
Publicado: (2018)

Contribution of TWIST1-EVX1 Axis in Invasiveness of Esophageal Squamous Cell Carcinoma; a Functional Study
por: Ardalan Khales, Sepideh, et al.
Publicado: (2022)

Immune Mechanisms in Myelodysplastic Syndrome
por: Glenthøj, Andreas, et al.
Publicado: (2016)

Optimization in Detection of Antigen‐Specific T Cells Through Differentially Labeled MHC Multimers
por: Pedersen, Natasja Wulff, et al.
Publicado: (2019)

DNA based neoepitope vaccination induces tumor control in syngeneic mouse models
por: Viborg, Nadia, et al.
Publicado: (2023)

Herpesvirus immunology in solid organ transplant recipients – liver transplant study (HISTORY): a retrospective and prospective observational cohort study
por: Suarez-Zdunek, Moises Alberto, et al.
Publicado: (2023)

An Analysis of Natural T Cell Responses to Predicted Tumor Neoepitopes
por: Bjerregaard, Anne-Mette, et al.
Publicado: (2017)

Corrigendum: An Analysis of Natural T Cell Responses to Predicted Tumor Neoepitopes
por: Bjerregaard, Anne-Mette, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_hp9p4750363532rpekdbn9q36g