Engineering Selectivity for Reduced Toxicity of Bacterial Kinase Inhibitors Using Structure-Guided Medicinal Chemistry

[Image: see text] Tuberculosis is a major global public health concern, and new drugs are needed to combat both the typical form and the increasingly common drug-resistant form of this disease. The essential tuberculosis kinase PknB is an attractive drug development target because of its central imp...

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Detalles Bibliográficos
Autores principales: Wlodarchak, Nathan, Feltenberger, John B., Ye, Zhengqing, Beczkiewicz, Jeffrey, Procknow, Rebecca, Yan, Gang, King, Troy M., Golden, Jennifer E., Striker, Rob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757511/
https://www.ncbi.nlm.nih.gov/pubmed/35035774
http://dx.doi.org/10.1021/acsmedchemlett.0c00580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757511/
https://www.ncbi.nlm.nih.gov/pubmed/35035774
http://dx.doi.org/10.1021/acsmedchemlett.0c00580

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