Synthesis, computational study and biological evaluation of 9-acridinyl and 1-coumarinyl-1,2,3-triazole-4-yl derivatives as topoisomerase II inhibitors

Topoisomerase (IIB) inhibitors have been involved in the therapies of tumour progression and have become a major focus for the development of anticancer agents. New three-component hybridised ligands, 1,4-disubstituted-1,2,3-triazoles (8–17), were synthesised via a 1,3-dipolar cycloaddition reaction...

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Detalles Bibliográficos
Autores principales: Abdel-Hafez, Gehan A., Mohamed, Abdel-Maaboud I., Youssef, Adel F., Simons, Claire, Aboraia, Ahmed S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757608/
https://www.ncbi.nlm.nih.gov/pubmed/35012398
http://dx.doi.org/10.1080/14756366.2021.2021898

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757608/
https://www.ncbi.nlm.nih.gov/pubmed/35012398
http://dx.doi.org/10.1080/14756366.2021.2021898

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