Synthesis, biological evaluation, and molecular docking of new series of antitumor and apoptosis inducers designed as VEGFR-2 inhibitors

Based on quinazoline, quinoxaline, and nitrobenzene scaffolds and on pharmacophoric features of VEGFR-2 inhibitors, 17 novel compounds were designed and synthesised. VEGFR-2 IC(50) values ranged from 60.00 to 123.85 nM for the new derivatives compared to 54.00 nM for sorafenib. Compounds 15(a), 15(b...

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Detalles Bibliográficos
Autores principales: Abdallah, Abdallah E., Mabrouk, Reda R., Al Ward, Maged Mohammed Saleh, Eissa, Sally I., Elkaeed, Eslam B., Mehany, Ahmed B. M., Abo-Saif, Mariam A., El-Feky, Ola A., Alesawy, Mohamed S., El-Zahabi, Mohamed Ayman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757611/
https://www.ncbi.nlm.nih.gov/pubmed/35012403
http://dx.doi.org/10.1080/14756366.2021.2017911

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757611/
https://www.ncbi.nlm.nih.gov/pubmed/35012403
http://dx.doi.org/10.1080/14756366.2021.2017911

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