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Current Perspective: 3D Spheroid Models Utilizing Human-Based Cells for Investigating Metabolism-Dependent Drug-Induced Liver Injury

Drug-induced liver injury (DILI) remains a leading cause for the withdrawal of approved drugs. This has significant financial implications for pharmaceutical companies, places increasing strain on global health services, and causes harm to patients. For these reasons, it is essential that in-vitro l...

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Detalles Bibliográficos
Autores principales: Cox, Christopher R., Lynch, Stephen, Goldring, Christopher, Sharma, Parveen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757888/
https://www.ncbi.nlm.nih.gov/pubmed/35047893
http://dx.doi.org/10.3389/fmedt.2020.611913