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Calmodulin binds the N-terminus of the functional amyloid Orb2A inhibiting fibril formation
The cytoplasmic polyadenylation element-binding protein Orb2 is a key regulator of long-term memory (LTM) in Drosophila. The N-terminus of the Orb2 isoform A is required for LTM and forms cross-β fibrils on its own. However, this N-terminus is not part of the core found in ex vivo fibrils. We previo...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758002/ https://www.ncbi.nlm.nih.gov/pubmed/35025866 http://dx.doi.org/10.1371/journal.pone.0259872 |