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Drosophila p53 isoforms have overlapping and distinct functions in germline genome integrity and oocyte quality control

p53 gene family members in humans and other organisms encode a large number of protein isoforms whose functions are largely undefined. Using Drosophila as a model, we find that a p53B isoform is expressed predominantly in the germline where it colocalizes with p53A into subnuclear bodies. It is only...

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Detalles Bibliográficos
Autores principales: Chakravarti, Ananya, Thirimanne, Heshani N, Brown, Savanna, Calvi, Brian R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758136/
https://www.ncbi.nlm.nih.gov/pubmed/35023826
http://dx.doi.org/10.7554/eLife.61389

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