A novel and accurate full-length HTT mouse model for Huntington’s disease

Here, we report the generation and characterization of a novel Huntington’s disease (HD) mouse model BAC226Q by using a bacterial artificial chromosome (BAC) system, expressing full-length human HTT with ~226 CAG-CAA repeats and containing endogenous human HTT promoter and regulatory elements. BAC22...

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Detalles Bibliográficos
Autores principales: Shenoy, Sushila A, Zheng, Sushuang, Liu, Wencheng, Dai, Yuanyi, Liu, Yuanxiu, Hou, Zhipeng, Mori, Susumu, Tang, Yi, Cheng, Jerry, Duan, Wenzhen, Li, Chenjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758142/
https://www.ncbi.nlm.nih.gov/pubmed/35023827
http://dx.doi.org/10.7554/eLife.70217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758142/
https://www.ncbi.nlm.nih.gov/pubmed/35023827
http://dx.doi.org/10.7554/eLife.70217

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