Robust T cell activation requires an eIF3-driven burst in T cell receptor translation

Activation of T cells requires a rapid surge in cellular protein synthesis. However, the role of translation initiation in the early induction of specific genes remains unclear. Here, we show human translation initiation factor eIF3 interacts with select immune system related mRNAs including those e...

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Detalles Bibliográficos
Autores principales: De Silva, Dasmanthie, Ferguson, Lucas, Chin, Grant H, Smith, Benjamin E, Apathy, Ryan A, Roth, Theodore L, Blaeschke, Franziska, Kudla, Marek, Marson, Alexander, Ingolia, Nicholas T, Cate, Jamie HD
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758144/
https://www.ncbi.nlm.nih.gov/pubmed/34970966
http://dx.doi.org/10.7554/eLife.74272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758144/
https://www.ncbi.nlm.nih.gov/pubmed/34970966
http://dx.doi.org/10.7554/eLife.74272

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