Cargando…

Aloin Regulates Matrix Metabolism and Apoptosis in Human Nucleus Pulposus Cells via the TAK1/NF-κB/NLRP3 Signaling Pathway

Intervertebral disc degeneration (IDD) is a degenerative disease that is characterized by decreased matrix synthesis and extra degradation, nucleus pulposus cells (NPCs) apoptosis, and infiltration of inflammatory factors. Aloin, a colored compound from aloe plants, has been shown to be effective ag...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Taiqiu, Li, Pengfei, Qiu, Jincheng, Hu, Wenjun, Li, Shaoguang, Shi, Huihong, Qiu, Xianjian, Huang, Dongsheng, Gao, Wenjie, Liang, Anjing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758297/ https://www.ncbi.nlm.nih.gov/pubmed/35035490 http://dx.doi.org/10.1155/2022/5865011

Ejemplares similares

Inverse Agonist of Retinoid-Related Orphan Receptor-Alpha Prevents Apoptosis and Degeneration in Nucleus Pulposus Cells via Upregulation of YAP
por: Liang, Tongzhou, et al.
Publicado: (2021)

Evaluating bone quality and asymmetrical aplasia of the thoracic vertebral body in Lenke 1A adolescent idiopathic scoliosis using hounsfield units
por: Chen, Taiqiu, et al.
Publicado: (2022)

Irisin enhances chondrogenic differentiation of human mesenchymal stem cells via Rap1/PI3K/AKT axis
por: Chen, Taiqiu, et al.
Publicado: (2022)

Collagen type II is downregulated in the degenerative nucleus pulposus and contributes to the degeneration and apoptosis of human nucleus pulposus cells
por: Lian, Chengjie, et al.
Publicado: (2017)

Melatonin reverses tumor necrosis factor-alpha-induced metabolic disturbance of human nucleus pulposus cells via MTNR1B/Gαi2/YAP signaling
por: Qiu, Xianjian, et al.
Publicado: (2022)

Irisin Ameliorates Intervertebral Disc Degeneration by Activating LATS/YAP/CTGF Signaling
por: Chen, Taiqiu, et al.
Publicado: (2022)

Comparison of anterior or posterior approach in surgical treatment of thoracic and lumbar tuberculosis: a retrospective case–control study
por: Qiu, Jincheng, et al.
Publicado: (2022)

Preoperative Decreased Hounsfield Unit Values of Cervical Vertebrae and the Relative Cross-Sectional Area of Flexion/Extension Paraspinal Muscles Are Novel Risk Factors for the Loss of Cervical Lordosis after Open-Door Laminoplasty
por: Hu, Wenjun, et al.
Publicado: (2023)

Self-amplifying loop of NF-κB and periostin initiated by PIEZO1 accelerates mechano-induced senescence of nucleus pulposus cells and intervertebral disc degeneration
por: Wu, Jinna, et al.
Publicado: (2022)

Autophagy attenuates the catabolic effect during inflammatory conditions in nucleus pulposus cells, as sustained by NF-κB and JNK inhibition
por: XU, KANG, et al.
Publicado: (2015)

Melatonin Reverses the Loss of Stemness Induced by TNF-α in Human Bone Marrow Mesenchymal Stem Cells through Upregulation of YAP Expression
por: Wang, Xudong, et al.
Publicado: (2019)

Corrigendum to “Melatonin Reverses the Loss of Stemness Induced by TNF-α in Human Bone Marrow Mesenchymal Stem Cells through Upregulation of YAP Expression”
por: Wang, Xudong, et al.
Publicado: (2022)

Identifying the key genes regulating mesenchymal stem cells chondrogenic differentiation: an in vitro study
por: Liang, Tongzhou, et al.
Publicado: (2022)

Inhibition of nuclear receptor RORα attenuates cartilage damage in osteoarthritis by modulating IL-6/STAT3 pathway
por: Liang, Tongzhou, et al.
Publicado: (2021)

Aloin in Pregnancy
por: Sircir, P. B.
Publicado: (1932)

On the Therapeutics of Aloin
por: Craig, William
Publicado: (1877)

Mitochondrial DNA induces nucleus pulposus cell pyroptosis via the TLR9-NF-κB-NLRP3 axis
por: Lu, Peng, et al.
Publicado: (2023)

Constructing intervertebral disc degeneration animal model: A review of current models
por: Liang, Tongzhou, et al.
Publicado: (2023)

Melatonin promotes bone marrow mesenchymal stem cell osteogenic differentiation and prevents osteoporosis development through modulating circ_0003865 that sponges miR-3653-3p
por: Wang, Xudong, et al.
Publicado: (2021)

Plasma, tissue and urinary levels of aloin in rats after the administration of pure aloin
por: Park, Mi-Young, et al.
Publicado: (2008)

Aloin Suppresses Lipopolysaccharide-Induced Inflammatory Response and Apoptosis by Inhibiting the Activation of NF-κB
por: Luo, Xuan, et al.
Publicado: (2018)

On Aloin: The Cathartic Principle of the Aloes
Publicado: (1851)

Sandwich structure Aloin-PVP/Aloin-PVP-PLA/PLA as a wound dressing to accelerate wound healing
por: Li, Weiping, et al.
Publicado: (2022)

Effects of the NF-κB/p53 signaling pathway on intervertebral disc nucleus pulposus degeneration
por: Zhang, Litao, et al.
Publicado: (2020)

TAK1ng control: TAK1 restrains NLRP3 activation
por: Mangan, Matthew Stephen, et al.
Publicado: (2018)

Notes on "Changed Aloin" and the Resin of Aloes
por: Craig, William
Publicado: (1875)

Notes on "Changed Aloin" and the Resin of Aloes
por: Craig, William
Publicado: (1875)

NF‐κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration
por: Zhang, Guang‐Zhi, et al.
Publicado: (2021)

LIPUS inhibits inflammation and catabolism through the NF‐κB pathway in human degenerative nucleus pulposus cells
por: Yi, Weiwei, et al.
Publicado: (2021)

Melatonin rescued interleukin 1β-impaired chondrogenesis of human mesenchymal stem cells
por: Gao, Bo, et al.
Publicado: (2018)

Evaluation of anti-infective potencies of formulated aloin A ointment and aloin A isolated from Aloe barbadensis Miller
por: Donkor, Addai-Mensah, et al.
Publicado: (2020)

Inducing Angiogenesis in the Nucleus Pulposus
por: Damle, Sheela R., et al.
Publicado: (2023)

The Role of Leptin on the Organization and Expression of Cytoskeleton Elements in Nucleus Pulposus Cells
por: Li, Zheng, et al.
Publicado: (2013)

Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc
por: Chen, Sheng, et al.
Publicado: (2022)

TAK-715 alleviated IL-1β-induced apoptosis and ECM degradation in nucleus pulposus cells and attenuated intervertebral disc degeneration ex vivo and in vivo
por: Wang, Kun, et al.
Publicado: (2023)

Melatonin Rescued Reactive Oxygen Species-Impaired Osteogenesis of Human Bone Marrow Mesenchymal Stem Cells in the Presence of Tumor Necrosis Factor-Alpha
por: Qiu, Xianjian, et al.
Publicado: (2019)

Expression and effects of leukemia inhibitory factor on nucleus pulposus degeneration
por: Xiao, Qiang, et al.
Publicado: (2019)

Impact of NF-κB pathway on the apoptosis-inflammation-autophagy crosstalk in human degenerative nucleus pulposus cells
por: Yi, Weiwei, et al.
Publicado: (2019)

Anemonin reduces hydrogen peroxide-induced oxidative stress, inflammation and extracellular matrix degradation in nucleus pulposus cells by regulating NOX4/NF-κB signaling pathway
por: Ma, Zhijia, et al.
Publicado: (2023)

Mechanical loading mediates human nucleus pulposus cell viability and extracellular matrix metabolism by activating of NF-κB
por: Zhang, Kai, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_m2jbiakou7ce7hc3u461eot05k