Prediction of clinical diagnosis of Alzheimer’s disease, vascular, mixed, and all-cause dementia by a polygenic risk score and APOE status in a community-based cohort prospectively followed over 17 years

The strongest genetic risk factor for Alzheimer’s disease (AD) is the ε4 allele of Apolipoprotein E (APOE) and recent genome-wide association meta-analyses have confirmed additional associated genetic loci with smaller effects. The aim of this study was to investigate the ability of an AD polygenic...

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Detalles Bibliográficos
Autores principales: Stocker, H., Perna, L., Weigl, K., Möllers, T., Schöttker, B., Thomsen, H., Holleczek, B., Rujescu, D., Brenner, H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758470/
https://www.ncbi.nlm.nih.gov/pubmed/32404947
http://dx.doi.org/10.1038/s41380-020-0764-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758470/
https://www.ncbi.nlm.nih.gov/pubmed/32404947
http://dx.doi.org/10.1038/s41380-020-0764-y

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