The acute phase protein lactoferrin is a key feature of Alzheimer’s disease and predictor of Aβ burden through induction of APP amyloidogenic processing

Amyloidogenic processing of the amyloid precursor protein (APP) forms the amyloid-β peptide (Aβ) component of pathognomonic extracellular plaques of AD. Additional early cortical changes in AD include neuroinflammation and elevated iron levels. Activation of the innate immune system in the brain is...

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Detalles Bibliográficos
Autores principales: Tsatsanis, Andrew, McCorkindale, Andrew N., Wong, Bruce X., Patrick, Ellis, Ryan, Tim M., Evans, Robert W., Bush, Ashley I., Sutherland, Greg T., Sivaprasadarao, Asipu, Guennewig, Boris, Duce, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Immediate Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758478/
https://www.ncbi.nlm.nih.gov/pubmed/34400772
http://dx.doi.org/10.1038/s41380-021-01248-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758478/
https://www.ncbi.nlm.nih.gov/pubmed/34400772
http://dx.doi.org/10.1038/s41380-021-01248-1

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