Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease

Mechanisms underlying the protective effect of apolipoprotein E (APOE) ε2 against Alzheimer disease (AD) are not well understood. We analyzed gene expression data derived from autopsied brains donated by 982 individuals including 135 APOE ɛ2/ɛ3 carriers. Complement pathway genes C4A and C4B were amo...

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Detalles Bibliográficos
Autores principales: Panitch, Rebecca, Hu, Junming, Chung, Jaeyoon, Zhu, Congcong, Meng, Gaoyuan, Xia, Weiming, Bennett, David A., Lunetta, Kathryn L., Ikezu, Tsuneya, Au, Rhoda, Stein, Thor D., Farrer, Lindsay A., Jun, Gyungah R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758485/
https://www.ncbi.nlm.nih.gov/pubmed/34480088
http://dx.doi.org/10.1038/s41380-021-01266-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758485/
https://www.ncbi.nlm.nih.gov/pubmed/34480088
http://dx.doi.org/10.1038/s41380-021-01266-z

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