PIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia

Familial Parkinson disease (PD) is associated with rare genetic mutations, but the etiology in most patients with sporadic (s)PD is largely unknown, and the basis for its progression to dementia (sPDD) is poorly characterized. We have identified that loss of IFNβ or IFNAR1, the receptor for IFNα/β,...

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Detalles Bibliográficos
Autores principales: Magalhaes, Joana, Tresse, Emilie, Ejlerskov, Patrick, Hu, Erling, Liu, Yawei, Marin, Andrea, Montalant, Alexia, Satriano, Letizia, Rundsten, Carsten Friis, Carlsen, Eva Maria Meier, Rydbirk, Rasmus, Sharifi-Zarchi, Ali, Andersen, Jesper Bøje, Aznar, Susana, Brudek, Tomasz, Khodosevich, Konstantin, Prinz, Marco, Perrier, Jean-François Marie, Sharma, Manu, Gasser, Thomas, Issazadeh-Navikas, Shohreh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758491/
https://www.ncbi.nlm.nih.gov/pubmed/34234281
http://dx.doi.org/10.1038/s41380-021-01207-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758491/
https://www.ncbi.nlm.nih.gov/pubmed/34234281
http://dx.doi.org/10.1038/s41380-021-01207-w

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