Impaired spike-gamma coupling of area CA3 fast-spiking interneurons as the earliest functional impairment in the App(NL-G-F) mouse model of Alzheimer’s disease

In Alzheimer’s disease (AD) the accumulation of amyloid-β (Aβ) correlates with degradation of cognition-relevant gamma oscillations. The gamma rhythm relies on proper neuronal spike-gamma coupling, specifically of fast-spiking interneurons (FSN). Here we tested the hypothesis that decrease in gamma...

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Detalles Bibliográficos
Autores principales: Arroyo-García, Luis Enrique, Isla, Arturo G., Andrade-Talavera, Yuniesky, Balleza-Tapia, Hugo, Loera-Valencia, Raúl, Alvarez-Jimenez, Laura, Pizzirusso, Giusy, Tambaro, Simone, Nilsson, Per, Fisahn, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758494/
https://www.ncbi.nlm.nih.gov/pubmed/34385602
http://dx.doi.org/10.1038/s41380-021-01257-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758494/
https://www.ncbi.nlm.nih.gov/pubmed/34385602
http://dx.doi.org/10.1038/s41380-021-01257-0

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