Alzheimer’s genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner

Although APP metabolism is being intensively investigated, a large fraction of its modulators is yet to be characterized. In this context, we combined two genome-wide high-content screenings to assess the functional impact of miRNAs and genes on APP metabolism and the signaling pathways involved. Th...

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Detalles Bibliográficos
Autores principales: Eysert, Fanny, Coulon, Audrey, Boscher, Emmanuelle, Vreulx, Anaїs-Camille, Flaig, Amandine, Mendes, Tiago, Hughes, Sandrine, Grenier-Boley, Benjamin, Hanoulle, Xavier, Demiautte, Florie, Bauer, Charlotte, Marttinen, Mikael, Takalo, Mari, Amouyel, Philippe, Desai, Shruti, Pike, Ian, Hiltunen, Mikko, Chécler, Frédéric, Farinelli, Mélissa, Delay, Charlotte, Malmanche, Nicolas, Hébert, Sébastien S., Dumont, Julie, Kilinc, Devrim, Lambert, Jean-Charles, Chapuis, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758496/
https://www.ncbi.nlm.nih.gov/pubmed/33144711
http://dx.doi.org/10.1038/s41380-020-00926-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758496/
https://www.ncbi.nlm.nih.gov/pubmed/33144711
http://dx.doi.org/10.1038/s41380-020-00926-w

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