Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor

Clonal hematopoiesis is a prevalent age-related condition associated with a greatly increased risk of hematologic disease; mutations in DNA methyltransferase 3A (DNMT3A) are the most common driver of this state. DNMT3A variants occur across the gene with some particularly associated with malignancy,...

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Detalles Bibliográficos
Autores principales: Huang, Yung-Hsin, Chen, Chun-Wei, Sundaramurthy, Venkatasubramaniam, Słabicki, Mikołaj, Hao, Dapeng, Watson, Caroline J., Tovy, Ayala, Reyes, Jaime M., Dakhova, Olga, Crovetti, Brielle R., Galonska, Christina, Lee, Minjung, Brunetti, Lorenzo, Zhou, Yubin, Tatton-Brown, Katrina, Huang, Yun, Cheng, Xiaodong, Meissner, Alexander, Valk, Peter J.M., Van Maldergem, Lionel, Sanders, Mathijs A., Blundell, Jamie R., Li, Wei, Ebert, Benjamin L., Goodell, Margaret A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758508/
https://www.ncbi.nlm.nih.gov/pubmed/34429321
http://dx.doi.org/10.1158/2159-8290.CD-21-0560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758508/
https://www.ncbi.nlm.nih.gov/pubmed/34429321
http://dx.doi.org/10.1158/2159-8290.CD-21-0560

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