Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification

While the cohort level accuracy of polygenic risk score has been widely assessed, uncertainty in PRS—estimates of genetic value at the individual level remains underexplored. Here we show that Bayesian PRS methods can estimate the variance of an individual’s PRS and can yield well-calibrated credibl...

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Detalles Bibliográficos
Autores principales: Ding, Yi, Hou, Kangcheng, Burch, Kathryn S., Lapinska, Sandra, Privé, Florian, Vilhjálmsson, Bjarni, Sankararaman, Sriram, Pasaniuc, Bogdan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758557/
https://www.ncbi.nlm.nih.gov/pubmed/34931067
http://dx.doi.org/10.1038/s41588-021-00961-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758557/
https://www.ncbi.nlm.nih.gov/pubmed/34931067
http://dx.doi.org/10.1038/s41588-021-00961-5

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