Cargando…

Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification

While the cohort level accuracy of polygenic risk score has been widely assessed, uncertainty in PRS—estimates of genetic value at the individual level remains underexplored. Here we show that Bayesian PRS methods can estimate the variance of an individual’s PRS and can yield well-calibrated credibl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ding, Yi, Hou, Kangcheng, Burch, Kathryn S., Lapinska, Sandra, Privé, Florian, Vilhjálmsson, Bjarni, Sankararaman, Sriram, Pasaniuc, Bogdan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758557/ https://www.ncbi.nlm.nih.gov/pubmed/34931067 http://dx.doi.org/10.1038/s41588-021-00961-5

Ejemplares similares

Polygenic scoring accuracy varies across the genetic ancestry continuum
por: Ding, Yi, et al.
Publicado: (2023)

Headaches and polygenic scores
por: Vilhjálmsson, Bjarni J., et al.
Publicado: (2019)

Estimation of regional polygenicity from GWAS provides insights into the genetic architecture of complex traits
por: Johnson, Ruth, et al.
Publicado: (2021)

Identifying and correcting for misspecifications in GWAS summary statistics and polygenic scores
por: Privé, Florian, et al.
Publicado: (2022)

Efficient variance components analysis across millions of genomes
por: Pazokitoroudi, Ali, et al.
Publicado: (2020)

Genetically-regulated pathway-polygenic risk score (GRPa-PRS): A risk stratification method to identify genetically regulated pathways in polygenic diseases
por: Li, Xiaoyang, et al.
Publicado: (2023)

Calibrated prediction intervals for polygenic scores across diverse contexts
por: Hou, Kangcheng, et al.
Publicado: (2023)

Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture
por: Hou, Kangcheng, et al.
Publicado: (2019)

HOW THE IMPACT OF CHRONIC PAIN ON COGNITION VARIES BY POLYGENIC RISK SCORE (PRS)
por: Song, Jieun
Publicado: (2019)

Polygenic risk score, psychosocial environment and the risk of attention-deficit/hyperactivity disorder
por: Østergaard, Søren D., et al.
Publicado: (2020)

Calculating Polygenic Risk Scores (PRS) in UK Biobank: A Practical Guide for Epidemiologists
por: Collister, Jennifer A., et al.
Publicado: (2022)

Pharmacogenomics polygenic risk score for drug response prediction using PRS-PGx methods
por: Zhai, Song, et al.
Publicado: (2022)

PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scores
por: Chen, Lawrence M., et al.
Publicado: (2018)

Attitudes among Parents towards Return of Disease-Related Polygenic Risk Scores (PRS) for Their Children
por: Terek, Shannon, et al.
Publicado: (2022)

Quantifying the contribution of dominance deviation effects to complex trait variation in biobank-scale data
por: Pazokitoroudi, Ali, et al.
Publicado: (2021)

Multi-PGS enhances polygenic prediction by combining 937 polygenic scores
por: Albiñana, Clara, et al.
Publicado: (2023)

Fast estimation of genetic correlation for biobank-scale data
por: Wu, Yue, et al.
Publicado: (2022)

Risk Stratification and Clinical Utility of Polygenic Risk Scores in Ophthalmology
por: Qassim, Ayub, et al.
Publicado: (2021)

Performance of polygenic risk scores in screening, prediction, and risk stratification: secondary analysis of data in the Polygenic Score Catalog
por: Hingorani, Aroon D, et al.
Publicado: (2023)

LDpred2: better, faster, stronger
por: Privé, Florian, et al.
Publicado: (2020)

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
por: de Rojas, Itziar, et al.
Publicado: (2021)

Improved genetic prediction of complex traits from individual-level data or summary statistics
por: Zhang, Qianqian, et al.
Publicado: (2021)

Evaluating the prognostic performance of a polygenic risk score for breast cancer risk stratification
por: Olsen, Maria, et al.
Publicado: (2021)

Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
por: de Rojas, Itziar, et al.
Publicado: (2023)

A Breast Cancer Polygenic Risk Score Is Feasible for Risk Stratification in the Norwegian Population
por: Akdeniz, Bayram Cevdet, et al.
Publicado: (2023)

Inference of locus-specific ancestry in closely related populations
por: Paşaniuc, Bogdan, et al.
Publicado: (2009)

A unifying framework for joint trait analysis under a non-infinitesimal model
por: Johnson, Ruth, et al.
Publicado: (2018)

Risk Stratification for Bipolar Disorder Using Polygenic Risk Scores Among Young High-Risk Adults
por: Biere, Silvia, et al.
Publicado: (2020)

A polygenic risk score for nasopharyngeal carcinoma shows potential for risk stratification and personalized screening
por: He, Yong-Qiao, et al.
Publicado: (2022)

Association of Childhood Exposure to Nitrogen Dioxide and Polygenic Risk Score for Schizophrenia With the Risk of Developing Schizophrenia
por: Horsdal, Henriette Thisted, et al.
Publicado: (2019)

PRS
por: Sphicas, Paris
Publicado: (2004)

Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction
por: Albiñana, Clara, et al.
Publicado: (2021)

Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score
por: Huynh-Le, Minh-Phuong, et al.
Publicado: (2022)

Impact of cross-ancestry genetic architecture on GWAS in admixed populations
por: Mester, Rachel, et al.
Publicado: (2023)

Demographic history mediates the effect of stratification on polygenic scores
por: Zaidi, Arslan A, et al.
Publicado: (2020)

Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores
por: Bianco, Cristiana, et al.
Publicado: (2021)

Risk stratification for hepatocellular cancer among patients with cirrhosis using a hepatic fat polygenic risk score
por: Thrift, Aaron P., et al.
Publicado: (2023)

Efficient toolkit implementing best practices for principal component analysis of population genetic data
por: Privé, Florian, et al.
Publicado: (2020)

Dissemination of Plastic Surgery Research: An Analysis of PRS and PRS-GO
por: Nasser, Jacob S., et al.
Publicado: (2022)

Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries
por: Liang, Yanyu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_np3ete82o1o4me04m4a8c22l31