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Hypoxia-inducible factor 1α induces osteo/odontoblast differentiation of human dental pulp stem cells via Wnt/β-catenin transcriptional cofactor BCL9

Accelerated dental pulp mineralization is a common complication in avulsed/luxated teeth, although the mechanisms underlying this remain unclear. We hypothesized that hypoxia due to vascular severance may induce osteo/odontoblast differentiation of dental pulp stem cells (DPSCs). This study examined...

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Detalles Bibliográficos
Autores principales: Orikasa, Shion, Kawashima, Nobuyuki, Tazawa, Kento, Hashimoto, Kentaro, Sunada-Nara, Keisuke, Noda, Sonoko, Fujii, Mayuko, Akiyama, Tetsu, Okiji, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758693/
https://www.ncbi.nlm.nih.gov/pubmed/35027586
http://dx.doi.org/10.1038/s41598-021-04453-8