Modeling uniquely human gene regulatory function via targeted humanization of the mouse genome

The evolution of uniquely human traits likely entailed changes in developmental gene regulation. Human Accelerated Regions (HARs), which include transcriptional enhancers harboring a significant excess of human-specific sequence changes, are leading candidates for driving gene regulatory modificatio...

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Detalles Bibliográficos
Autores principales: Dutrow, Emily V., Emera, Deena, Yim, Kristina, Uebbing, Severin, Kocher, Acadia A., Krenzer, Martina, Nottoli, Timothy, Burkhardt, Daniel B., Krishnaswamy, Smita, Louvi, Angeliki, Noonan, James P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758698/
https://www.ncbi.nlm.nih.gov/pubmed/35027568
http://dx.doi.org/10.1038/s41467-021-27899-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758698/
https://www.ncbi.nlm.nih.gov/pubmed/35027568
http://dx.doi.org/10.1038/s41467-021-27899-w

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