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Single-cell transcriptomics of human iPSC differentiation dynamics reveal a core molecular network of Parkinson’s disease

Parkinson’s disease (PD) is the second-most prevalent neurodegenerative disorder, characterized by the loss of dopaminergic neurons (mDA) in the midbrain. The underlying mechanisms are only partly understood and there is no treatment to reverse PD progression. Here, we investigated the disease mecha...

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Detalles Bibliográficos
Autores principales: Novak, Gabriela, Kyriakis, Dimitrios, Grzyb, Kamil, Bernini, Michela, Rodius, Sophie, Dittmar, Gunnar, Finkbeiner, Steven, Skupin, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758783/
https://www.ncbi.nlm.nih.gov/pubmed/35027645
http://dx.doi.org/10.1038/s42003-021-02973-7