Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy

Little is known about how the observed fat-specific pattern of 3D-spatial genome organisation is established. Here we report that adipocyte-specific knockout of the gene encoding nuclear envelope transmembrane protein Tmem120a disrupts fat genome organisation, thus causing a lipodystrophy syndrome....

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Detalles Bibliográficos
Autores principales: Czapiewski, Rafal, Batrakou, Dzmitry G., de las Heras, Jose I., Carter, Roderick N., Sivakumar, Aishwarya, Sliwinska, Magdalena, Dixon, Charles R., Webb, Shaun, Lattanzi, Giovanna, Morton, Nicholas M., Schirmer, Eric C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758788/
https://www.ncbi.nlm.nih.gov/pubmed/35027552
http://dx.doi.org/10.1038/s41467-021-27869-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758788/
https://www.ncbi.nlm.nih.gov/pubmed/35027552
http://dx.doi.org/10.1038/s41467-021-27869-2

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