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Tubastatin A maintains adult skeletal muscle stem cells in a quiescent state ex vivo and improves their engraftment ability in vivo

Adult skeletal muscle stem cells (MuSCs) are important for muscle regeneration and constitute a potential source of cell therapy. However, upon isolation, MuSCs rapidly exit quiescence and lose transplantation potency. Maintenance of the quiescent state in vitro preserves MuSC transplantation effici...

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Detalles Bibliográficos
Autores principales: Arjona, Marina, Goshayeshi, Armon, Rodriguez-Mateo, Cristina, Brett, Jamie O., Both, Pieter, Ishak, Heather, Rando, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758944/
https://www.ncbi.nlm.nih.gov/pubmed/35021050
http://dx.doi.org/10.1016/j.stemcr.2021.11.012