Use of Physiologically Based Pharmacokinetic Modeling to Predict Human Gut Microbial Conversion of Daidzein to S-Equol

[Image: see text] A physiologically based pharmacokinetic (PBPK) model was developed for daidzein and its metabolite S-equol. Anaerobic in vitro incubations of pooled fecal samples from S-equol producers and nonproducers allowed definition of the kinetic constants. PBPK model-based predictions for t...

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Detalles Bibliográficos
Autores principales: Wang, Qianrui, Spenkelink, Bert, Boonpawa, Rungnapa, Rietjens, Ivonne M.C.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759082/
https://www.ncbi.nlm.nih.gov/pubmed/34855380
http://dx.doi.org/10.1021/acs.jafc.1c03950

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759082/
https://www.ncbi.nlm.nih.gov/pubmed/34855380
http://dx.doi.org/10.1021/acs.jafc.1c03950

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