PARP1 as a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome

Poly(ADP‐ribose) polymerase 1 (PARP1) is a key mediator of various forms of DNA damage repair and plays an important role in the progression of several cancer types. The enzyme is activated by binding to DNA single-strand and double-strand breaks. Its contribution to chromatin remodeling makes PARP1...

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Detalles Bibliográficos
Autores principales: Kontandreopoulou, Christina-Nefeli, Diamantopoulos, Panagiotis T., Tiblalexi, Despina, Giannakopoulou, Nefeli, Viniou, Nora-Athina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759124/
https://www.ncbi.nlm.nih.gov/pubmed/34529761
http://dx.doi.org/10.1182/bloodadvances.2021004638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759124/
https://www.ncbi.nlm.nih.gov/pubmed/34529761
http://dx.doi.org/10.1182/bloodadvances.2021004638

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