Cargando…

Polyphosphate expression by cancer cell extracellular vesicles mediates binding of factor XII and contact activation

Extracellular vesicles (EV) have been implicated in diverse biological processes, including intracellular communication, transport of nucleic acids, and regulation of vascular function. Levels of EVs are elevated in cancer, and studies suggest that EV may stimulate thrombosis in patients with cancer...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shim, Young Jun, Chatterjee, Victor, Swaidani, Shadi, Alluri, Ravi Kumar, Kundu, Suman, Merkulova, Alona, Angelini, Dana, You, Dewen, Whitney, Samantha A., Feener, Edward P., Barnard, John, Schmaier, Alvin H., Khorana, Alok A., McCrae, Keith R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Hematology 2021
Materias:	Thrombosis and Hemostasis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759128/ https://www.ncbi.nlm.nih.gov/pubmed/34597365 http://dx.doi.org/10.1182/bloodadvances.2021005116

Ejemplares similares

Model for surface-dependent factor XII activation: the roles of factor XII heavy chain domains
por: Shamanaev, Aleksandr, et al.
Publicado: (2022)

Anti-HK antibody inhibits the plasma contact system by blocking prekallikrein and factor XI activation in vivo
por: Chen, Zu-Lin, et al.
Publicado: (2022)

Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus
por: Silasi, Robert, et al.
Publicado: (2021)

The interplay between tissue plasminogen activator domains and fibrin structures in the regulation of fibrinolysis: kinetic and microscopic studies
por: Longstaff, Colin, et al.
Publicado: (2011)

Activated protein C cofactor function of protein S: a critical role for Asp95 in the EGF1-like domain
por: Andersson, Helena M., et al.
Publicado: (2010)

Harmful or Physiologic: Diagnosing Fibrinolysis Shutdown in a Trauma Cohort With Rotational Thromboelastometry
por: Gomez-Builes, J. Carolina, et al.
Publicado: (2018)

Platelets inhibit apoptotic lung epithelial cell death and protect mice against infection-induced lung injury
por: Bain, William, et al.
Publicado: (2019)

Targeting complement activation in COVID-19
por: Kulkarni, Hrishikesh S., et al.
Publicado: (2020)

Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition
por: Yu, Jia, et al.
Publicado: (2020)

COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection
por: Al-Samkari, Hanny, et al.
Publicado: (2020)

COVID-19 coagulopathy, thrombosis, and bleeding
por: Chan, Noel C., et al.
Publicado: (2020)

Frequency of venous thromboembolism in 6513 patients with COVID-19: a retrospective study
por: Hill, Jason B., et al.
Publicado: (2020)

A toolkit for the collection of thrombosis-related data elements in COVID-19 clinical studies
por: Siegal, Deborah M., et al.
Publicado: (2020)

Incidence of symptomatic, image-confirmed venous thromboembolism following hospitalization for COVID-19 with 90-day follow-up
por: Salisbury, Richard, et al.
Publicado: (2020)

Postdischarge thromboembolic outcomes and mortality of hospitalized patients with COVID-19: the CORE-19 registry
por: Giannis, Dimitrios, et al.
Publicado: (2021)

A factor VIIIa–mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice
por: Østergaard, Henrik, et al.
Publicado: (2021)

COVID-19 and VITT: same or different?
por: Arepally, Gowthami M.
Publicado: (2021)

von Willebrand factor antigen levels are associated with burden of rare nonsynonymous variants in the VWF gene
por: Sadler, Brooke, et al.
Publicado: (2021)

An alternate covalent form of platelet αIIbβ3 integrin that resides in focal adhesions and has altered function
por: Pijning, Aster E., et al.
Publicado: (2021)

Novel mechanism regulating tissue factor activity
por: Nieuwland, Rienk
Publicado: (2021)

The incidence of cancer-associated thrombosis is increasing over time
por: Mahajan, Anjlee, et al.
Publicado: (2022)

The binding of autotaxin to integrins mediates hyperhomocysteinemia-potentiated platelet activation and thrombosis in mice and humans
por: Han, Lulu, et al.
Publicado: (2021)

Role of ribosomal RNA released from red cells in blood coagulation in zebrafish and humans
por: Alharbi, Abdulmajeed, et al.
Publicado: (2021)

Most anti-PF4 antibodies in vaccine-induced immune thrombotic thrombocytopenia are transient
por: Schönborn, Linda, et al.
Publicado: (2022)

PKM2 promotes neutrophil activation and cerebral thromboinflammation: therapeutic implications for ischemic stroke
por: Dhanesha, Nirav, et al.
Publicado: (2022)

Contact and intrinsic coagulation pathways are activated and associated with adverse clinical outcomes in COVID-19
por: Henderson, Michael W., et al.
Publicado: (2022)

Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19
por: Wygrecka, Malgorzata, et al.
Publicado: (2022)

Novel cysteine substitution p.(Cys1084Tyr) causes variable expressivity of qualitative and quantitative VWF defects
por: Rawley, Orla, et al.
Publicado: (2022)

A novel mouse model of type 2N VWD was developed by CRISPR/Cas9 gene editing and recapitulates human type 2N VWD
por: Shi, Qizhen, et al.
Publicado: (2022)

Differential impact of tamoxifen and aromatase inhibitors on thrombin generation: the prospective HEMOBREAST cohort
por: Blondon, Marc, et al.
Publicado: (2022)

Structure of shear-induced platelet aggregated clot formed in an in vitro arterial thrombosis model
por: Kim, Dongjune A., et al.
Publicado: (2022)

SIPA in 10 milliseconds: VWF tentacles agglomerate and capture platelets under high shear
por: Liu, Zixiang Leonardo, et al.
Publicado: (2022)

Second-dose VITT: rare but real
por: Pavord, Sue, et al.
Publicado: (2022)

Laminin G1 residues of protein S mediate its TFPI cofactor function and are competitively regulated by C4BP
por: Teraz-Orosz, Adrienn, et al.
Publicado: (2022)

Whole-exome analysis of adolescents with low VWF and heavy menstrual bleeding identifies novel genetic associations
por: Sadler, Brooke, et al.
Publicado: (2022)

A flow cytometric assay to detect platelet-activating antibodies in VITT after ChAdOx1 nCov-19 vaccination
por: Handtke, Stefan, et al.
Publicado: (2021)

Rate of thrombosis in children and adolescents hospitalized with COVID-19 or MIS-C
por: Whitworth, Hilary, et al.
Publicado: (2021)

Anti–platelet factor 4 antibodies causing VITT do not cross-react with SARS-CoV-2 spike protein
por: Greinacher, Andreas, et al.
Publicado: (2021)

Neutrophil extracellular traps promote tPA-induced brain hemorrhage via cGAS in mice with stroke
por: Wang, Ranran, et al.
Publicado: (2021)

Anticoagulation in cancer-associated thromboembolism with thrombocytopenia: a prospective, multicenter cohort study
por: Carney, Brian J., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ncuqee9pa940r89nlhre48bpm0