Low guanine content and biased nucleotide distribution in vertebrate mtDNA can cause overestimation of non-CpG methylation

Mitochondrial DNA (mtDNA) methylation in vertebrates has been hotly debated for over 40 years. Most contrasting results have been reported following bisulfite sequencing (BS-seq) analyses. We addressed whether BS-seq experimental and analysis conditions influenced the estimation of the levels of met...

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Detalles Bibliográficos
Autores principales: Okada, Takashi, Sun, Xin, McIlfatrick, Stephen, St. John, Justin C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Standard Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759572/
https://www.ncbi.nlm.nih.gov/pubmed/35047811
http://dx.doi.org/10.1093/nargab/lqab119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759572/
https://www.ncbi.nlm.nih.gov/pubmed/35047811
http://dx.doi.org/10.1093/nargab/lqab119

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