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Low guanine content and biased nucleotide distribution in vertebrate mtDNA can cause overestimation of non-CpG methylation
Mitochondrial DNA (mtDNA) methylation in vertebrates has been hotly debated for over 40 years. Most contrasting results have been reported following bisulfite sequencing (BS-seq) analyses. We addressed whether BS-seq experimental and analysis conditions influenced the estimation of the levels of met...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759572/ https://www.ncbi.nlm.nih.gov/pubmed/35047811 http://dx.doi.org/10.1093/nargab/lqab119 |