cADPR induced calcium influx mediates axonal degeneration caused by paclitaxel

Activation of the NAD hydrolase domain of Sarm1 mediates axonal degeneration caused by chemotherapy drugs, but the downstream events are unknown. In this issue, Li and colleagues (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202106080) demonstrate that cADPR, a breakdown product of NAD, mediates...

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Detalles Bibliográficos
Autor principal: Höke, Ahmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759606/
https://www.ncbi.nlm.nih.gov/pubmed/35019936
http://dx.doi.org/10.1083/jcb.202112021
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author Höke, Ahmet
author_facet Höke, Ahmet
author_sort Höke, Ahmet
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description Activation of the NAD hydrolase domain of Sarm1 mediates axonal degeneration caused by chemotherapy drugs, but the downstream events are unknown. In this issue, Li and colleagues (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202106080) demonstrate that cADPR, a breakdown product of NAD, mediates paclitaxel-induced axonal degeneration by promoting influx of calcium into the axons.
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spelling pubmed-87596062022-07-14 cADPR induced calcium influx mediates axonal degeneration caused by paclitaxel Höke, Ahmet J Cell Biol Spotlight Activation of the NAD hydrolase domain of Sarm1 mediates axonal degeneration caused by chemotherapy drugs, but the downstream events are unknown. In this issue, Li and colleagues (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202106080) demonstrate that cADPR, a breakdown product of NAD, mediates paclitaxel-induced axonal degeneration by promoting influx of calcium into the axons. Rockefeller University Press 2022-01-12 /pmc/articles/PMC8759606/ /pubmed/35019936 http://dx.doi.org/10.1083/jcb.202112021 Text en © 2022 Höke https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Höke, Ahmet
cADPR induced calcium influx mediates axonal degeneration caused by paclitaxel
title cADPR induced calcium influx mediates axonal degeneration caused by paclitaxel
title_full cADPR induced calcium influx mediates axonal degeneration caused by paclitaxel
title_fullStr cADPR induced calcium influx mediates axonal degeneration caused by paclitaxel
title_full_unstemmed cADPR induced calcium influx mediates axonal degeneration caused by paclitaxel
title_short cADPR induced calcium influx mediates axonal degeneration caused by paclitaxel
title_sort cadpr induced calcium influx mediates axonal degeneration caused by paclitaxel
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759606/
https://www.ncbi.nlm.nih.gov/pubmed/35019936
http://dx.doi.org/10.1083/jcb.202112021
work_keys_str_mv AT hokeahmet cadprinducedcalciuminfluxmediatesaxonaldegenerationcausedbypaclitaxel

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