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cADPR induced calcium influx mediates axonal degeneration caused by paclitaxel
Activation of the NAD hydrolase domain of Sarm1 mediates axonal degeneration caused by chemotherapy drugs, but the downstream events are unknown. In this issue, Li and colleagues (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202106080) demonstrate that cADPR, a breakdown product of NAD, mediates...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Rockefeller University Press
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759606/ https://www.ncbi.nlm.nih.gov/pubmed/35019936 http://dx.doi.org/10.1083/jcb.202112021 |