Design, synthesis and biological evaluation of 1-Aryl-5-(4-arylpiperazine-1-carbonyl)-1H-tetrazols as novel microtubule destabilizers

A series of 1-aryl-5-(4-arylpiperazine-1-carbonyl)-1H-tetrazols as microtubule destabilizers were designed, synthesised and evaluated for anticancer activity. Based on bioisosterism, we introduced the tetrazole moiety containing the hydrogen-bond acceptors as B-ring of XRP44X analogues. The key inte...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Chao, Li, Yuelin, Liu, Zi, Wang, Zeyu, Liu, Zihan, Man, Shuai, Zhang, Yujing, Bao, Kai, Wu, Yingliang, Guan, Qi, Zuo, Daiying, Zhang, Weige
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759721/
https://www.ncbi.nlm.nih.gov/pubmed/33522315
http://dx.doi.org/10.1080/14756366.2020.1759582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759721/
https://www.ncbi.nlm.nih.gov/pubmed/33522315
http://dx.doi.org/10.1080/14756366.2020.1759582

Ejemplares similares