Discovery of new non-pyrimidine scaffolds as Plasmodium falciparum DHFR inhibitors by fragment-based screening

In various malaria-endemic regions, the appearance of resistance has precluded the use of pyrimidine-based antifolate drugs. Here, a three-step fragment screening was used to identify new non-pyrimidine Plasmodium falciparum dihydrofolate reductase (PfDHFR) inhibitors. Starting from a 1163-fragment...

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Detalles Bibliográficos
Autores principales: Hoarau, Marie, Vanichtanankul, Jarunee, Srimongkolpithak, Nitipol, Vitsupakorn, Danoo, Yuthavong, Yongyuth, Kamchonwongpaisan, Sumalee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759724/
https://www.ncbi.nlm.nih.gov/pubmed/33530764
http://dx.doi.org/10.1080/14756366.2020.1854244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759724/
https://www.ncbi.nlm.nih.gov/pubmed/33530764
http://dx.doi.org/10.1080/14756366.2020.1854244

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