Click chemistry based synthesis, cytotoxic activity and molecular docking of novel triazole-thienopyrimidine hybrid glycosides targeting EGFR

In the current study, new thienopyrimidine conjugates bearing 1,2,3-triazole core and different sugar moieties have been designed and synthesized by Cu(I)-catalysed click dipolar cycloaddition. The cytotoxic activity of the synthesised conjugates 2, 5, 7, and 13–18 was studied against HCT-116 and MC...

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Detalles Bibliográficos
Autores principales: Khattab, Reham R., Alshamari, Asma K., Hassan, Allam A., Elganzory, Hussein H., El-Sayed, Wael A., Awad, Hanem M., Nossier, Eman S., Hassan, Nasser A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759726/
https://www.ncbi.nlm.nih.gov/pubmed/33504239
http://dx.doi.org/10.1080/14756366.2020.1871335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759726/
https://www.ncbi.nlm.nih.gov/pubmed/33504239
http://dx.doi.org/10.1080/14756366.2020.1871335

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