Pharmacophore-guided repurposing of fibrates and retinoids as GPR40 allosteric ligands with activity on insulin release

A classical drug repurposing approach was applied to find new putative GPR40 allosteric binders. A two-step computational protocol was set up, based on an initial pharmacophoric-based virtual screening of the DrugBank database of known drugs, followed by docking simulations to confirm the interactio...

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Detalles Bibliográficos
Autores principales: Cione, Erika, Caroleo, Maria Cristina, Kagechika, Hiroyuki, Manetti, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759729/
https://www.ncbi.nlm.nih.gov/pubmed/33525941
http://dx.doi.org/10.1080/14756366.2020.1864629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759729/
https://www.ncbi.nlm.nih.gov/pubmed/33525941
http://dx.doi.org/10.1080/14756366.2020.1864629

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