Targeting allosteric sites of human aromatase: a comprehensive in-silico and in-vitro workflow to find potential plant-based anti-breast cancer therapeutics

Recent findings suggested several allosteric pockets on human aromatase that could be utilised for the development of new modulators able to inhibit this enzyme in a new mechanism. Herein, we applied an integrated in-silico-based approach supported by in-vitro enzyme-based and cell-based validation...

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Detalles Bibliográficos
Autores principales: Alhadrami, Hani A., Sayed, Ahmed M., Melebari, Sami A., Khogeer, Asem A., Abdulaal, Wesam H., Al-Fageeh, Mohamed B., Algahtani, Mohammad, Rateb, Mostafa E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759730/
https://www.ncbi.nlm.nih.gov/pubmed/34139914
http://dx.doi.org/10.1080/14756366.2021.1937145