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β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity
The dysregulation of energy homeostasis in obesity involves multihormone resistance. Although leptin and insulin resistance have been well characterized, catecholamine resistance remains largely unexplored. Murine β3-adrenergic receptor expression in adipocytes is orders of magnitude higher compared...
Autores principales: | Valentine, Joseph M., Ahmadian, Maryam, Keinan, Omer, Abu-Odeh, Mohammad, Zhao, Peng, Zhou, Xin, Keller, Mark P., Gao, Hui, Yu, Ruth T., Liddle, Christopher, Downes, Michael, Zhang, Jin, Lusis, Aldons J., Attie, Alan D., Evans, Ronald M., Rydén, Mikael, Saltiel, Alan R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759781/ https://www.ncbi.nlm.nih.gov/pubmed/34847077 http://dx.doi.org/10.1172/JCI153357 |
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