Positive and negative selection shape the human naive B cell repertoire

Although negative selection of developing B cells in the periphery is well described, yet poorly understood, evidence of naive B cell positive selection remains elusive. Using 2 humanized mouse models, we demonstrate that there was strong skewing of the expressed immunoglobulin repertoire upon trans...

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Detalles Bibliográficos
Autores principales: Chen, Jeff W., Schickel, Jean-Nicolas, Tsakiris, Nikolaos, Sng, Joel, Arbogast, Florent, Bouis, Delphine, Parisi, Daniele, Gera, Ruchi, Boeckers, Joshua M., Delmotte, Fabien R., Veselits, Margaret, Schuetz, Catharina, Jacobsen, Eva-Maria, Posovszky, Carsten, Schulz, Ansgar S., Schwarz, Klaus, Clark, Marcus R., Menard, Laurence, Meffre, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759783/
https://www.ncbi.nlm.nih.gov/pubmed/34813502
http://dx.doi.org/10.1172/JCI150985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759783/
https://www.ncbi.nlm.nih.gov/pubmed/34813502
http://dx.doi.org/10.1172/JCI150985

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