Cargando…
Positive and negative selection shape the human naive B cell repertoire
Although negative selection of developing B cells in the periphery is well described, yet poorly understood, evidence of naive B cell positive selection remains elusive. Using 2 humanized mouse models, we demonstrate that there was strong skewing of the expressed immunoglobulin repertoire upon trans...
Autores principales: | Chen, Jeff W., Schickel, Jean-Nicolas, Tsakiris, Nikolaos, Sng, Joel, Arbogast, Florent, Bouis, Delphine, Parisi, Daniele, Gera, Ruchi, Boeckers, Joshua M., Delmotte, Fabien R., Veselits, Margaret, Schuetz, Catharina, Jacobsen, Eva-Maria, Posovszky, Carsten, Schulz, Ansgar S., Schwarz, Klaus, Clark, Marcus R., Menard, Laurence, Meffre, Eric |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759783/ https://www.ncbi.nlm.nih.gov/pubmed/34813502 http://dx.doi.org/10.1172/JCI150985 |
Ejemplares similares
-
CD4 T cell autophagy is integral to memory maintenance
por: Murera, Diane, et al.
Publicado: (2018) -
BCG Disease in SCID: Three Decades of Experience in a Pediatric Transplant Center
por: Cocchi, Nicoletta, et al.
Publicado: (2021) -
The Changing Landscape of Naive T Cell Receptor Repertoire With Human Aging
por: Egorov, Evgeny S., et al.
Publicado: (2018) -
Guinea pig immunoglobulin VH and VL naïve repertoire analysis
por: Matsuzawa, Shun, et al.
Publicado: (2018) -
Somatic Hypermutation Shapes the Antibody Repertoire of Memory B Cells in Humans
por: Meffre, Eric, et al.
Publicado: (2001)