Neoantigen-reactive CD8(+) T cells affect clinical outcome of adoptive cell therapy with tumor-infiltrating lymphocytes in melanoma

BACKGROUND: Neoantigen-driven recognition and T cell–mediated killing contribute to tumor clearance following adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs). Yet how diversity, frequency, and persistence of expanded neoepitope-specific CD8(+) T cells derived from TIL infusion...

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Detalles Bibliográficos
Autores principales: Kristensen, Nikolaj Pagh, Heeke, Christina, Tvingsholm, Siri A., Borch, Annie, Draghi, Arianna, Crowther, Michael D., Carri, Ibel, Munk, Kamilla K., Holm, Jeppe Sejerø, Bjerregaard, Anne-Mette, Bentzen, Amalie Kai, Marquard, Andrea M., Szallasi, Zoltan, McGranahan, Nicholas, Andersen, Rikke, Nielsen, Morten, Jönsson, Göran B., Donia, Marco, Svane, Inge Marie, Hadrup, Sine Reker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Clinical Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759789/
https://www.ncbi.nlm.nih.gov/pubmed/34813506
http://dx.doi.org/10.1172/JCI150535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759789/
https://www.ncbi.nlm.nih.gov/pubmed/34813506
http://dx.doi.org/10.1172/JCI150535

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