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Neoantigen-reactive CD8(+) T cells affect clinical outcome of adoptive cell therapy with tumor-infiltrating lymphocytes in melanoma

BACKGROUND: Neoantigen-driven recognition and T cell–mediated killing contribute to tumor clearance following adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs). Yet how diversity, frequency, and persistence of expanded neoepitope-specific CD8(+) T cells derived from TIL infusion...

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Detalles Bibliográficos
Autores principales:	Kristensen, Nikolaj Pagh, Heeke, Christina, Tvingsholm, Siri A., Borch, Annie, Draghi, Arianna, Crowther, Michael D., Carri, Ibel, Munk, Kamilla K., Holm, Jeppe Sejerø, Bjerregaard, Anne-Mette, Bentzen, Amalie Kai, Marquard, Andrea M., Szallasi, Zoltan, McGranahan, Nicholas, Andersen, Rikke, Nielsen, Morten, Jönsson, Göran B., Donia, Marco, Svane, Inge Marie, Hadrup, Sine Reker
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Clinical Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759789/ https://www.ncbi.nlm.nih.gov/pubmed/34813506 http://dx.doi.org/10.1172/JCI150535

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