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Microglia-specific knock-down of Bmal1 improves memory and protects mice from high fat diet-induced obesity

Microglia play a critical role in maintaining neural function. While microglial activity follows a circadian rhythm, it is not clear how this intrinsic clock relates to their function, especially in stimulated conditions such as in the control of systemic energy homeostasis or memory formation. In t...

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Detalles Bibliográficos
Autores principales: Wang, Xiao-Lan, Kooijman, Sander, Gao, Yuanqing, Tzeplaeff, Laura, Cosquer, Brigitte, Milanova, Irina, Wolff, Samantha E. C., Korpel, Nikita, Champy, Marie-France, Petit-Demoulière, Benoit, Goncalves Da Cruz, Isabelle, Sorg-Guss, Tania, Rensen, Patrick C. N., Cassel, Jean-Christophe, Kalsbeek, Andries, Boutillier, Anne-Laurence, Yi, Chun-Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760060/
https://www.ncbi.nlm.nih.gov/pubmed/34050326
http://dx.doi.org/10.1038/s41380-021-01169-z