Cargando…

Lithium increases mitochondrial respiration in iPSC-derived neural precursor cells from lithium responders

Lithium (Li), valproate (VPA) and lamotrigine (LTG) are commonly used to treat bipolar disorder (BD). While their clinical efficacy is well established, the mechanisms of action at the molecular level are still incompletely understood. Here we investigated the molecular effects of Li, LTG and VPA tr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Osete, Jordi Requena, Akkouh, Ibrahim A., de Assis, Denis Reis, Szabo, Attila, Frei, Evgeniia, Hughes, Timothy, Smeland, Olav B., Steen, Nils Eiel, Andreassen, Ole A., Djurovic, Srdjan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760072/ https://www.ncbi.nlm.nih.gov/pubmed/34075196 http://dx.doi.org/10.1038/s41380-021-01164-4

Ejemplares similares

Transcriptional and functional effects of lithium in bipolar disorder iPSC-derived cortical spheroids
por: Osete, Jordi Requena, et al.
Publicado: (2023)

Using iPSC Models to Understand the Role of Estrogen in Neuron–Glia Interactions in Schizophrenia and Bipolar Disorder
por: Reis de Assis, Denis, et al.
Publicado: (2021)

A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia
por: Szabo, Attila, et al.
Publicado: (2021)

Derivation and Molecular Characterization of a Morphological Subpopulation of Human iPSC Astrocytes Reveal a Potential Role in Schizophrenia and Clozapine Response
por: Akkouh, Ibrahim A, et al.
Publicado: (2021)

Exploring lithium’s transcriptional mechanisms of action in bipolar disorder: a multi-step study
por: Akkouh, Ibrahim A., et al.
Publicado: (2019)

Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking
por: Hindley, Guy, et al.
Publicado: (2021)

Extensive bidirectional genetic overlap between bipolar disorder and cardiovascular disease phenotypes
por: Rødevand, Linn, et al.
Publicado: (2021)

Genetic loci shared between major depression and intelligence with mixed directions of effect
por: Bahrami, Shahram, et al.
Publicado: (2021)

Expression of TCN1 in Blood is Negatively Associated with Verbal Declarative Memory Performance
por: Akkouh, Ibrahim A., et al.
Publicado: (2018)

The Endogenous Hallucinogen and Trace Amine N,N-Dimethyltryptamine (DMT) Displays Potent Protective Effects against Hypoxia via Sigma-1 Receptor Activation in Human Primary iPSC-Derived Cortical Neurons and Microglia-Like Immune Cells
por: Szabo, Attila, et al.
Publicado: (2016)

Expression of ANK3 moderates the association between childhood trauma and affective traits in severe mental disorders
por: Aas, Monica, et al.
Publicado: (2023)

Shared genetic architecture between neuroticism, coronary artery disease and cardiovascular risk factors
por: Torgersen, Kristin, et al.
Publicado: (2021)

Shared Genetic Loci Between Schizophrenia and White Blood Cell Counts Suggest Genetically Determined Systemic Immune Abnormalities
por: Steen, Nils Eiel, et al.
Publicado: (2023)

All-Optical Electrophysiology in hiPSC-Derived Neurons With Synthetic Voltage Sensors
por: Puppo, Francesca, et al.
Publicado: (2021)

Identification of novel genomic risk loci shared between common epilepsies and psychiatric disorders
por: Karadag, Naz, et al.
Publicado: (2023)

Copy number variants (CNVs): a powerful tool for iPSC-based modelling of ASD
por: Drakulic, Danijela, et al.
Publicado: (2020)

Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms
por: Rødevand, Linn, et al.
Publicado: (2021)

Association between complement component 4A expression, cognitive performance and brain imaging measures in UK Biobank
por: O'Connell, Kevin S., et al.
Publicado: (2022)

Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes
por: Drange, Ole Kristian, et al.
Publicado: (2019)

Banking on iPSC- Is it Doable and is it Worthwhile
por: Solomon, Susan, et al.
Publicado: (2014)

Roadblocks in the Path of iPSC to the Clinic
por: Garreta, Elena, et al.
Publicado: (2018)

iPSC Bioprinting: Where are We at?
por: Romanazzo, Sara, et al.
Publicado: (2019)

Maturing iPSC-Derived Cardiomyocytes
por: Tang, Bor Luen
Publicado: (2020)

iPSC for modeling neurodegenerative disorders
por: Valadez-Barba, Valeria, et al.
Publicado: (2020)

The shared genetic risk architecture of neurological and psychiatric disorders: a genome-wide analysis
por: Smeland, Olav B., et al.
Publicado: (2023)

Role of Jnk1 in development of neural precursors revealed by iPSC modeling
por: Zhang, Qian, et al.
Publicado: (2016)

Differences in white blood cell proportions between schizophrenia cases and controls are influenced by medication and variations in time of day
por: Villar, Jonelle D., et al.
Publicado: (2023)

Runaway multi-allelic copy number variation at the α-defensin locus in African and Asian populations
por: Hughes, Timothy, et al.
Publicado: (2020)

iPSC-Derived Macrophages: The Differentiation Protocol Affects Cell Immune Characteristics and Differentiation Trajectories
por: Klepikova, Anna, et al.
Publicado: (2022)

Pro-maturational Effects of Human iPSC-Derived Cortical Astrocytes upon iPSC-Derived Cortical Neurons
por: Hedegaard, Anne, et al.
Publicado: (2020)

Recycling Lithium from Waste Lithium Bromide to Produce Lithium Hydroxide
por: Gao, Wenjie, et al.
Publicado: (2021)

Lithium: Lithium intoxication: case report
Publicado: (2021)

Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation
por: Frei, Oleksandr, et al.
Publicado: (2019)

Phenotype-specific differences in polygenicity and effect size distribution across functional annotation categories revealed by AI-MiXeR
por: Shadrin, Alexey A, et al.
Publicado: (2020)

Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships
por: Maçon, Anthony L. B., et al.
Publicado: (2016)

iPSC-based model of viral infection
Publicado: (2012)

Chromatin looping is needed for iPSC induction
por: Hu, Ji-Fan, et al.
Publicado: (2014)

iPSC-MSCs and islet allograft tolerance
por: Wang, Tong-Song, et al.
Publicado: (2015)

Human iPSC banking: barriers and opportunities
por: Huang, Ching-Ying, et al.
Publicado: (2019)

Application of iPSC to Modelling of Respiratory Diseases
por: Calvert, Ben A., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_6fjjgb4gv917rksqdv09vbeofj